Low Thyroid and High Insulin

Insulin can reduce metabolic rate due to insulin’s antagonistic effect upon the stimulatory, or thermogenic action of thyroid and adrenal hormones. Patients with adult onset diabetes have the typical triad of hyperinsulinism, parathyroid dominance and hypothyroidism. These endocrine changes are present long before clinical manifestations of diabetes. Attention to endocrine balance will aid in improving the resting metabolic rate, improve glucose control, normalize lipids as well as aid in weight loss. (Piolino, et al 1990)(Iitaka, et al. 2000)

Low Thyroid May Contribute To High Cholesterol

Patients with subclinical hypothyroidism have higher total cholesterol, LDL, triglyceride, apo B levels and LDL/HDL ratio compared to control groups. (Cabral, et al. 2004) Hypothyroidism affects cardiac muscle contraction and contributes to high blood pressure due to increase stiffness of blood vessels and peripheral vascular resistance. Studies have shown that subclinical hypothyroidism may be an independent risk factor for the development of coronary artery disease, as well as congestive heart failure in older adults who have elevated TSH levels. (JAMA 2006)

Low Thyroid and High Calcium

It is known that an increase in free intracellular calcium in adipocytes reduces their lypolytic response to catecholamines. In other words excess calcium has an effect of blunting the fat burning enzymes in fat cells, thus contributing to weight gain or an inability to lose weight. Parasympathetic dominant individuals who have hypothyroidism can often have a corresponding elevation of PTH, which increases calcium concentrations in fat cells. (McCarty, et.al. 2003)